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KMID : 0359819930220070815
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Journal of Korean Neurosurgical Society
1993 Volume.22 No. 7 p.815 ~ p.827
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Histopathological Changes of the Renal Arterial Wall After Bipolar Coagulation in Experimental Rat Models
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이상구
박철완/김광명/김영수/고용/오성훈/오석진/김남규/정환영
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Abstract
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The bipolar coagulator has been frequently used in reducing the size of aneurysmal neck or dissecting the aneurysmal sac. Howere the effeccts of bipolar current on the wall of vessels have not been adcquately documented. The author studied the
histopathological changes of the renal artrial wall after bipolar coagulation.
Thirty one Sprague-Dawley strain rats of both sexes and of various age were used. Under penthobarbital anesthesia, the left renal artery was coagulated with bipolar forcep just distal to it's origin from the aorta. The rats were divided into two
groups
: Group A was coagulated for two seconds : Group B for one second. The coagulation sites of vessels were examined giossly and microscopically in three and six months, respectively.
@ES The results were summerized as followings :
@EN 1) In both three and six months groups : the internal elastic membrane and elastic fibers were destructed, fragmented and thinned ; the medial smooth muscle cells were damaged and decreased in number.
2) While the endothelial cells were severely desquamated and scattered in three months group, but there was an evidence of partial rogeneration of endothelium and reduction of inflammatory reaction in six months group. Fibrosis was more
augmented
in
six month group than three month group.
3) Between group A and B. There seemed to be no definite discrepancy in histopathological findings.
4) Pseudoaneurysms were developed in 72.2% of three months group and in 61.5% of six months group, but there was no significant statistical difference in the rate of pseudoaneurysm formation between the two groups (p>0.01, X2=0.393)
5) Above findings suggest that the pseudoaneurysm which might be produced by bipolar coagulation of vessels in the neurosurgical operation, would be progressed to the true aneurysm if continuous hemodynamic factors are exerted upon the
pseudoaneurysm.
Therefore, it is desirable that the bipolar current should be used very catiously during the surgery of cerebrovascular disease.
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